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The ALK2 interaction network in U2OS cells Summary of ALK2 interactors identified in U2OS cells Discussion: theintracellular ALK2 interaction network in U2OS cells Apart from typical signaling components, the ALK2 interaction network shows a range of regulatory proteins involved in receptor sorting and turnover These include classical chaperones, components of the ubiquitination pathway and the…
Investigation of ALK2 interactions in Hek293 cells The following BMP4 signal cascade components were chosen for investigation: ALK2 wild type receptor ALK2 mutated receptors: R206H (causes FOP (Fibrodysplasia ossificans progressiva)) Q207D (constitutive active) K235R (dominant negative) ALK6 wild type receptor ALK6 mutated receptor (I200K): causes brachydactyl (shortness of the fingers and toes) BMPRII: type II…
Introduction to Fibrodysplasia ossificans progressiva (FOP, Münchmeyer syndrome) Fibrodysplasia ossificans progressiva (FOP, Münchmeyer syndrome) First mentioned in England around 1740 Orphan disease, approx. one patient per 2 million individuals Approx. 600 cases are documented Autosomal dominant Average life span: 45 years Early indicator: deformed big toes Progressive incidents of inflammation, followed by differentiation of inflamed…